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Specifically, in a study to develop a therapeutic strategy for osteoarthritis, Que was shown to increase expression levels of SIRT1, PGC-1, NRF1 and NFR2, TFAM, and phospho-AMPK in osteoarthritis rats, confirming the hypothesis that Que might act via the AMPK/SIRT1 signaling pathway (Qiu et al., 2018)

Myostatin Inhibition: Myostatin (GDF-8) is an endogenous protein that inhibits muscle growth

It has a favorable topical tolerability signal in cosmetics and preclinical models, but there is no published human trial quantifying its side effects, and no systemic/injectable safety data at all

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